Department of Quality Assurance, SSR College of Pharmacy, Sayli Road, Silvassa, U.T of Dadra Nagar and Haveli, 396230, India.
Curr Drug Res Rev. 2024;16(3):381-394. doi: 10.2174/0125899775295960240406073630.
Peptides represent a class of natural molecules with diverse physiological functions, including hormone regulation, neurotransmission, and immune modulation. In recent years, peptide- based therapeutics have gained significant attention in pharmaceutical research and development due to their high specificity, efficacy, and relatively low toxicity. This review provides an overview of the current landscape of peptide drug development, highlighting the challenges faced in their formulation and delivery and the innovative strategies employed to overcome these hurdles. The review explores the wide range of applications of peptide drugs in treating various diseases, including HIV, multiple sclerosis, osteoporosis, chronic pain, diabetes, and cancer. Examples of FDA-approved peptide drugs and ongoing clinical trials are presented, showcasing the continuous advancements in peptide-based therapeutics across different therapeutic areas. This review underscores the promising potential of peptide drugs as targeted and effective treatments for a multitude of medical conditions, offering improved therapeutic outcomes and enhanced patient care.
肽是一类具有多种生理功能的天然分子，包括激素调节、神经递质传递和免疫调节。近年来，基于肽的治疗药物在药物研发中受到了极大关注，因为它们具有高度的特异性、疗效和相对较低的毒性。
本文综述了肽类药物开发的现状，重点介绍了在其制剂和递送中面临的挑战，以及为克服这些障碍而采用的创新策略。
本文探讨了肽类药物在治疗各种疾病（包括 HIV、多发性硬化症、骨质疏松症、慢性疼痛、糖尿病和癌症）中的广泛应用。本文还介绍了已获 FDA 批准的肽类药物和正在进行的临床试验，展示了不同治疗领域中基于肽的治疗方法的不断进步。
本文强调了肽类药物作为针对多种医疗状况的靶向有效治疗方法的巨大潜力，为改善治疗效果和提高患者护理水平带来了希望。
