Pantano P, Matteucci C, di Piero V, Pozzilli C, Faedda M T, Grasso M G, Argentino C, Cruccu G, Carolei A
Department of Neurological Sciences, University of Rome, Italy.
Clin Nucl Med. 1991 Dec;16(12):898-903. doi: 10.1097/00003072-199112000-00003.
The Xe-133 inhalation method was used to study rCBF in 12 patients with partial epilepsy during the interictal phase. SPECT images evidenced a focal CBF defect in 10 out of 12 patients, while quantitative analysis showed CBF abnormalities in all the patients. The focal CBF defect corresponded to the site of EEG abnormalities in nine patients. Additional low-flow areas beyond the EEG focus were found. Five patients presented a significant CBF decrease in the cerebellar hemisphere contralateral to the EEG focus. In five patients with unilateral EEG abnormalities, a CBF reduction was found in the contralateral cerebral hemisphere, mirror to the EEG focus. Finally, a widespread CBF decrease involving one or both cerebral hemispheres was observed in seven patients. Global and rCBF values were not correlated with age, duration of disease, frequency of seizures, secondary generalization, or specific therapy. SPECT may be useful in evaluating EEG epileptic foci, and quantitative SPECT allows the detection of functional effects of the epileptic focus on anatomically connected remote areas, probably due to the decrease of afferent inputs (diaschisis phenomenon).
采用Xe - 133吸入法对12例部分性癫痫患者发作间期的局部脑血流量（rCBF）进行研究。单光子发射计算机断层扫描（SPECT）图像显示，12例患者中有10例存在局部脑血流量缺损，而定量分析表明所有患者均有脑血流量异常。9例患者的局部脑血流量缺损与脑电图（EEG）异常部位相对应。发现了脑电图焦点以外的其他低血流区域。5例患者脑电图焦点对侧的小脑半球脑血流量显著降低。在5例单侧脑电图异常的患者中，对侧大脑半球出现脑血流量减少，与脑电图焦点呈镜像关系。最后，7例患者观察到一个或两个大脑半球广泛的脑血流量减少。全脑和局部脑血流量值与年龄、病程、癫痫发作频率、继发性全面发作或特定治疗均无相关性。SPECT可能有助于评估脑电图癫痫病灶，定量SPECT能够检测癫痫病灶对解剖学上相连的远处区域的功能影响，这可能是由于传入输入减少（交叉性小脑神经机能联系不能现象）所致。
