Fish D R, Lewis T T, Brooks D J, Zilkha E, Wise R J, Kendall B E
Institute of Neurology, Queen Square, London, UK.
J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1584-8. doi: 10.1136/jnnp.50.12.1584.
Stable xenon-enhanced X-ray computed tomography (XeCT) was used to measure the regional cerebral blood flow (rCBF) of 12 patients with drug resistant partial epilepsy and a marked unilateral focus on electroencephalography (EEG). Interictal mean rCBF of fixed regions of interest (ROIs) was reduced by 25% in the cortex of the epileptogenic cerebral lobe compared with the same regions on the contralateral side (p less than 0.02). Six control scans showed a mean side to side cortical difference in rCBF of 14%, whereas the epileptogenic focus was associated with a reduction in the cortical rCBF of greater than 30% in six out of the 12 patients. In an additional patient with partial epilepsy XeCT demonstrated significant focal hypoperfusion when interictal EEGs and conventional CT scans showed no abnormalities.
采用稳定氙增强X射线计算机断层扫描（XeCT）测量了12例药物难治性部分性癫痫患者的局部脑血流量（rCBF），这些患者脑电图（EEG）显示有明显的单侧病灶。与对侧相同区域相比，致痫脑叶皮质中固定感兴趣区（ROI）的发作间期平均rCBF降低了25%（p<0.02）。6次对照扫描显示rCBF的皮质平均左右差异为14%，而在12例患者中的6例中，致痫灶与皮质rCBF降低超过30%有关。在另外1例部分性癫痫患者中，当发作间期EEG和传统CT扫描无异常时，XeCT显示有明显的局灶性灌注不足。
