杜仲绿叶中的环烯醚萜类化合物。

Iridoids from the green leaves of Eucommia ulmoides.

作者信息

Takamura Chika, Hirata Tetsuya, Ueda Taro, Ono Masateru, Miyashita Hiroyuki, Ikeda Tsuyoshi, Nohara Toshihiro

机构信息

Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

出版信息

J Nat Prod. 2007 Aug;70(8):1312-6. doi: 10.1021/np0780046. Epub 2007 Aug 10.

DOI:10.1021/np0780046

PMID:17691745

Abstract

The bark of Eucommia ulmoides is a well-known crude drug in oriental medicine, and its leaves have been consumed as a beverage. From the green leaves of this plant, three new iridoids (1-3) were isolated, together with 12 known compounds. Compound 1 is the first iridoid possessing a saturated bond between C-3 and C-4 and having an ether linkage between C-3 and C-2 of the glucose unit. Furthermore, 2 and 3 may be regarded as the first naturally occurring conjugates of an iridoid and an amino acid.

摘要

杜仲树皮是东方医学中一种著名的天然药物，其叶子也被用作饮品。从这种植物的绿叶中，分离出了三种新的环烯醚萜（1 - 3）以及12种已知化合物。化合物1是首个在C - 3和C - 4之间具有饱和键且在葡萄糖单元的C - 3和C - 2之间具有醚键的环烯醚萜。此外，化合物2和3可被视为环烯醚萜与氨基酸的首个天然共轭物。