Wang Rui, Xiao Dan, Bian Yan-Hong, Zhang Xiao-Yue, Li Bang-Jing, Ding Li-Sheng, Peng Shu-Lin
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
J Nat Prod. 2008 Jul;71(7):1254-7. doi: 10.1021/np070598p. Epub 2008 Jun 17.
Four new iridoids, valeriotetrates B and C (1 and 2), 8-methylvalepotriate (3), and 1,5-dihydroxy-3,8-epoxyvalechlorine A (4), together with three known iridoids, were isolated from the roots of Valeriana wallichii. The structures of the new compounds were elucidated by analysis of 1D and 2D NMR and HRESIMS data. Compound 4 is an unusual iridoid bearing a C-10 chloro group and an oxo bridge connecting C-3 and C-8, resulting in a rigid skeleton.
从缬草的根中分离出四种新的环烯醚萜，缬草四酯B和C（1和2）、8-甲基缬草三酯（3）以及1,5-二羟基-3,8-环氧缬草氯醛A（4），同时还分离出三种已知的环烯醚萜。通过一维和二维核磁共振以及高分辨电喷雾电离质谱数据的分析确定了新化合物的结构。化合物4是一种不寻常的环烯醚萜，带有一个C-10氯基团以及一个连接C-3和C-8的氧桥，形成了一个刚性骨架。
