(-)-海兔二烯的首次全合成及结构重新认定
First total synthesis and structural reassignment of (-)-aplysiallene.
作者信息
Wang Jian, Pagenkopf Brian L
机构信息
Department of Chemistry, University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5B7, Canada.
出版信息
Org Lett. 2007 Aug 30;9(18):3703-6. doi: 10.1021/ol701797e. Epub 2007 Aug 11.
PMID:17691801
Abstract
The first total synthesis of (-)-aplysiallene has been completed in 16 steps and features a key sequential Mukaiyama aerobic oxidative cyclization to prepare the fused bis-THF core. The original stereochemical assignment has been revised as shown.
摘要
（-）-海兔二烯的首次全合成已通过16步完成，其特点是关键的顺序式向山有氧氧化环化反应，用于制备稠合双四氢呋喃核心。原来的立体化学归属已如所示进行了修订。
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