Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, PR China.
Org Lett. 2013 Feb 1;15(3):456-9. doi: 10.1021/ol400016c. Epub 2013 Jan 11.
A highly efficient method for the construction of 3a,6a-dihydrofuro[2,3-b]furan derivatives has been developed via a novel bicyclization, which is very valuable for the synthesis of fused furofuran compounds since it is time-saving and catalyst-free. Based on the bicyclization, a coupled domino strategy has been developed to directly construct 3a,6a-dihydrofuro[2,3-b]furan derivatives from methyl ketones.
开发了一种高效的 3a,6a-二氢呋喃并[2,3-b]呋喃衍生物的构建方法，通过新颖的双环化反应实现，由于省时且无催化剂，因此对于稠合呋喃化合物的合成非常有价值。基于双环化反应，开发了一种偶联的多米诺策略，可直接从甲基酮构建 3a,6a-二氢呋喃并[2,3-b]呋喃衍生物。
