Ashina Messoud
Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark.
CNS Neurol Disord Drug Targets. 2007 Aug;6(4):238-9. doi: 10.2174/187152707781387297.
The pathophysiology of tension-type headache is still far from clear, although recent advances in basic and clinical research have increased our knowledge about mechanisms underlying this disorder. Experimental studies suggest that increased excitability of the CNS generated by repetitive and sustained pericranial myofascial input may be responsible for transformation of episodic tension-type headache into chronic form. Future studies should focus on the identification of the source of peripheral nociception in patients with tension-type headache and the development of more effective and specific treatment modalities.
紧张型头痛的病理生理学仍远未明确，尽管基础和临床研究的最新进展增加了我们对该疾病潜在机制的认识。实验研究表明，重复性和持续性颅周肌筋膜输入所产生的中枢神经系统兴奋性增加，可能是发作性紧张型头痛转变为慢性形式的原因。未来的研究应聚焦于确定紧张型头痛患者外周伤害性刺激的来源，并开发更有效、更具特异性的治疗方法。
