Gorski J, Gannon F
Annu Rev Physiol. 1976;38:425-50. doi: 10.1146/annurev.ph.38.030176.002233.
In this review, we have traced the path of estradiol from its entry into the cell to the time of its release from the receptor. We feel that all of the current models are limited in one respect or another. We have examined most critically those currently most in vogue. The entry of estradiol into the cell is widely assumed to be simply a matter of diffusion. We have highlighted data that suggest the existence of a protein-mediated transport, but feel that the available data are too limited to make a definite conclusion.
在本综述中，我们追踪了雌二醇从进入细胞到从受体释放的过程。我们认为目前所有的模型都在某些方面存在局限性。我们对当前最流行的那些模型进行了最为严格的审视。人们普遍认为雌二醇进入细胞仅仅是扩散的问题。我们着重强调了表明存在蛋白质介导转运的数据，但认为现有数据过于有限，无法得出明确结论。
