Richardson Lucy E, Dudhia Jayesh, Clegg Peter D, Smith Roger
Department of Veterinary Clinical Sciences, The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
Trends Biotechnol. 2007 Sep;25(9):409-16. doi: 10.1016/j.tibtech.2007.07.009. Epub 2007 Aug 9.
Stem cells have evoked considerable excitement in the animal-owning public because of the promise that stem cell technology could deliver tissue regeneration for injuries for which natural repair mechanisms do not deliver functional recovery and for which current therapeutic strategies have minimal effectiveness. This review focuses on the current use of stem cells within veterinary medicine, whose practitioners have used mesenchymal stem cells (MSCs), recovered from either bone marrow or adipose tissue, in clinical cases primarily to treat strain-induced tendon injury in the horse. The background on why this treatment has been advocated, the data supporting its use and the current encouraging outcome from clinical use in horses treated with bone-marrow-derived cells are presented together with the future challenges of stem-cell therapy for the veterinary community.
干细胞在养宠物的公众中引起了极大的关注，因为干细胞技术有望实现组织再生，用于那些自然修复机制无法实现功能恢复且当前治疗策略效果甚微的损伤。本综述聚焦于干细胞在兽医学中的当前应用，兽医从业者已将从骨髓或脂肪组织中获取的间充质干细胞（MSCs）用于临床病例，主要治疗马的应变性肌腱损伤。本文介绍了提倡这种治疗的背景、支持其使用的数据以及目前用骨髓来源细胞治疗马的临床应用所取得的令人鼓舞的结果，同时也阐述了干细胞治疗对兽医界未来的挑战。
