Syk deficiency in human non-releaser lung mast cells.
作者信息
Gomez Gregorio, Schwartz Lawrence, Kepley Christopher
出版信息
Clin Immunol. 2007 Oct;125(1):112-5. doi: 10.1016/j.clim.2007.06.006. Epub 2007 Aug 10.
Abstract
摘要
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Syk deficiency in human non-releaser lung mast cells.人类非释放型肺肥大细胞中的Syk缺陷
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Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.一旦磷酸化，蛋白酪氨酸激酶 Syk 的羧基末端的酪氨酸与信号蛋白相互作用，包括 TULA-2，一种肥大细胞脱粒的负调节剂。
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The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells.支架蛋白 prohibitin 是肥大细胞抗原刺激信号所必需的。
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Antigen-induced reduction in mast cell and basophil functional responses due to reduced Syk protein levels.由于Syk蛋白水平降低，抗原诱导肥大细胞和嗜碱性粒细胞功能反应降低。
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Syk-kinase inhibition prevents mast cell activation in nasal polyps.Src 激酶抑制可预防鼻息肉中肥大细胞的激活。
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本文引用的文献
1
Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells.FcγRIIa而非FcγRIIb在源自皮肤的人肥大细胞上组成性且功能性地表达。
J Immunol. 2006 Jul 1;177(1):694-701. doi: 10.4049/jimmunol.177.1.694.
2
Evidence for human mast cell nonreleaser phenotype.
J Allergy Clin Immunol. 2003 Aug;112(2):457-9. doi: 10.1067/mai.2003.1671.
3
Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes.人皮肤来源的肥大细胞能够增殖，同时保持其特征性的功能和蛋白酶表型。
Blood. 2001 Apr 1;97(7):2045-52. doi: 10.1182/blood.v97.7.2045.
4
Multiple defects in Fc epsilon RI signaling in Syk-deficient nonreleaser basophils and IL-3-induced recovery of Syk expression and secretion.Syk缺陷型非释放型嗜碱性粒细胞中FcεRI信号传导的多种缺陷以及IL-3诱导的Syk表达和分泌的恢复。
J Immunol. 2000 Nov 15;165(10):5913-20. doi: 10.4049/jimmunol.165.10.5913.
5
The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils.
Am J Respir Cell Mol Biol. 2000 Oct;23(4):566-71. doi: 10.1165/ajrcmb.23.4.4123.
6
Syk deficiency in nonreleaser basophils.非释放型嗜碱性粒细胞中的Syk缺陷
J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):279-84. doi: 10.1016/s0091-6749(99)70367-2.
7
Nonreleasing basophils convert to releasing basophils by culturing with IL-3.非释放型嗜碱性粒细胞通过与白细胞介素-3培养转化为释放型嗜碱性粒细胞。
J Allergy Clin Immunol. 1996 Jun;97(6):1279-87. doi: 10.1016/s0091-6749(96)70196-3.
8
9
Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies.使用新型抗胰蛋白酶单克隆抗体和抗糜蛋白酶抗体通过免疫组织化学检测人肥大细胞的MCT和MCTC类型
J Histochem Cytochem. 1989 Oct;37(10):1509-15. doi: 10.1177/37.10.2674273.
10
A comparative study of releasing and nonreleasing human basophils: nonreleasing basophils lack an early component of the signal transduction pathway that follows IgE cross-linking.释放型与非释放型人嗜碱性粒细胞的比较研究：非释放型嗜碱性粒细胞缺乏IgE交联后信号转导途径的早期成分。
J Allergy Clin Immunol. 1990 Jun;85(6):1020-9. doi: 10.1016/0091-6749(90)90046-7.
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