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心肌病的“还原论”观点。

A "reductionist" view of cardiomyopathy.

作者信息

Dimmeler Stefanie, Zeiher Andreas M

机构信息

Department of Internal Medicine III, J.W. Goethe University, 60590 Frankfurt, Germany.

出版信息

Cell. 2007 Aug 10;130(3):401-2. doi: 10.1016/j.cell.2007.07.028.

DOI:10.1016/j.cell.2007.07.028
PMID:17693248
Abstract

Oxidative stress due to the generation of reactive oxygen species has been implicated in many diseases. Rajasekaran et al. (2007) now make the surprising discovery that its counterpart "reductive stress," caused by an increase in reduced glutathione, contributes to cardiomyopathy triggered by protein aggregation.

摘要

由活性氧生成导致的氧化应激与许多疾病有关。拉贾塞卡兰等人(2007年)现在有了一个惊人的发现,即其对应的“还原应激”(由还原型谷胱甘肽增加引起)会导致由蛋白质聚集引发的心肌病。

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