Keltz Martin D, Gera Puja S, Skorupski Josh, Stein Daniel E
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, St. Luke's Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10019, USA.
Fertil Steril. 2007 Aug;88(2):350-3. doi: 10.1016/j.fertnstert.2006.11.123.
To compare FSH, LH, estrogen, and P flare response following 1 mg lupron injection in poor responders with or without pretreatment with oral contraceptive pills (OCPs).
Prospective study.
University hospital.
PATIENT(S): Poor responders undergoing IVF flare protocol from October 2002 to November 2003.
INTERVENTION(S): Patients were divided into group A, who received OCPs before IVF cycle (n = 12), and group B, who did not (n = 7). One milligram Lupron was injected SC after measuring day 2 serum FSH, LH, estrogen, and P. After 24 hours, serum hormones were measured before lupron administration.
MAIN OUTCOME MEASURE(S): Serum FSH, LH, estrogen, and P before and after 1 mg lupron
RESULT(S): Basal FSH was similar in both groups (8.6 +/- 4.5 vs. 9.6 +/- 2.9 mIU/mL). Group A patients had significantly lower day 2 FSH (3.6 +/- 3.6 vs. 10.1 +/- 4.2 mIU/mL; P<.05). After lupron, although both groups had a significant rise in FSH and LH, mean LH rise in group B was 39.5 +/- 31 mIU/mL versus 11.3 +/- 4.6 mIU/mL in group A (P<.05).
CONCLUSION(S): Pretreatment with OCPs in GnRH agonist flare protocol suppresses pre-Lupron FSH but does not blunt FSH flare. It blunts LH flare, which may be beneficial.
比较在未使用或使用口服避孕药（OCP）预处理的低反应者中，注射1毫克亮丙瑞林后促卵泡生成素（FSH）、促黄体生成素（LH）、雌激素和孕酮的激发反应。
前瞻性研究。
大学医院。
2002年10月至2003年11月接受体外受精（IVF）激发方案的低反应者。
患者分为A组（IVF周期前接受OCP，n = 12）和B组（未接受，n = 7）。在测量第2天血清FSH、LH、雌激素和孕酮后，皮下注射1毫克亮丙瑞林。24小时后，在注射亮丙瑞林前测量血清激素。
1毫克亮丙瑞林前后的血清FSH、LH、雌激素和孕酮。
两组基础FSH相似（8.6±4.5对9.6±2.9 mIU/mL）。A组患者第2天FSH显著降低（3.6±3.6对10.1±4.2 mIU/mL；P<0.05）。注射亮丙瑞林后，虽然两组FSH和LH均显著升高，但B组LH平均升高39.5±31 mIU/mL，而A组为11.3±4.6 mIU/mL（P<0.05）。
在GnRH激动剂激发方案中，用OCP预处理可抑制注射亮丙瑞林前的FSH，但不会减弱FSH激发反应。它会减弱LH激发反应，这可能是有益的。
