Rajan M T, Banerjee T K
Department of Zoology, Banaras Hindu University, Varanasi, India.
Ecotoxicol Environ Saf. 1991 Oct;22(2):139-52. doi: 10.1016/0147-6513(91)90054-s.
The toxic effects of 0.3 ppm (96-hr LC50 value) of mercuric chloride solution on the epidermis of Heteropneustes fossilis at different time intervals have been studied. The epidermis reacts instantaneously by secreting a profuse amount of slime, especially due to hyperactivity of the goblet mucous cells which subsequently degenerate and get lost. Later, all other cell types also get entangled in the degenerative process. The damaged cells, especially the club cells, get sloughed at the surface, forming a thick crust of debris from the degenerating cells. Side-by-side regeneration of the epidermis also continues from the lower layers of the intact tissue with the addition of all the cell types. However, even before attaining maturity, these budding cells, especially the club cells, show signs of degeneration, their degeneration occurring faster than their regeneration. Thus most of the space left behind by the degenerated club cells gets quickly filled with haphazardly arranged polygonal epithelial cells, giving the epidermis an altogether different morphology.
研究了0.3 ppm（96小时半数致死浓度值）氯化汞溶液在不同时间间隔对印度胡鲶表皮的毒性作用。表皮会立即做出反应，分泌大量黏液，这尤其归因于杯状黏液细胞的过度活跃，随后这些细胞会退化并消失。之后，所有其他细胞类型也会卷入退化过程。受损细胞，尤其是棒状细胞，会在表面脱落，形成由退化细胞构成的厚厚的碎屑硬皮。完整组织的下层也会同时进行表皮的再生，所有细胞类型都会增加。然而，即使在成熟之前，这些新生细胞，尤其是棒状细胞，就显示出退化迹象，它们的退化速度比再生速度更快。因此，退化的棒状细胞留下的大部分空间很快就会被排列杂乱的多边形上皮细胞填满，使表皮呈现出完全不同的形态。
