Kirubagaran R, Joy K P
Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India.
Ecotoxicol Environ Saf. 1988 Apr;15(2):171-9. doi: 10.1016/0147-6513(88)90069-3.
In Clarias batrachus methylmercuric chloride (CH3HgCl) was 1.18 and 10.05 times more toxic than mercuric chloride (HgCl2) and emisan 6 (methoxyethyl mercury chloride), respectively, for 96 hr. A similar trend was observed at 24, 48, and 72 hr. Exposure of the catfish to sublethal concentrations of these mercurials for 14 and 28 days caused progressive changes in the kidney. The diameter of the proximal convoluted tubules was increased, the epithelial cells were hypertrophied, and the lumen was reduced and filled with secretory material and sloughed-off cells. In 14-day emisan 6-treated fish, some glomeruli were also degenerated. Exposure of the catfish to toxicologically safe concentrations of the mercurials for 90 days caused vacuolation, atrophy, and extensive damage of the tubules in HgCl2-and CH3HgCl-treated fish, and hypertrophy and vacuolation of epithelial cells of some tubules in the emisan 6-treated fish. Regeneration was noticed in the 90-day HgCl2-exposed group. After 180 days of exposure, however, histology of the kidney appeared normal in all the groups.
在胡子鲶中，甲基氯化汞（CH3HgCl）对其96小时的毒性分别比氯化汞（HgCl2）和埃米散6（甲氧基乙基氯化汞）高1.18倍和10.05倍。在24小时、48小时和72小时时也观察到类似趋势。将鲶鱼暴露于这些汞化合物的亚致死浓度下14天和28天，会导致肾脏发生渐进性变化。近端曲管直径增加，上皮细胞肥大，管腔缩小并充满分泌物质和脱落细胞。在经埃米散6处理14天的鱼中，一些肾小球也发生了退化。将鲶鱼暴露于这些汞化合物的毒理学安全浓度下90天，会导致经HgCl2和CH3HgCl处理的鱼的肾小管出现空泡化、萎缩和广泛损伤，以及经埃米散6处理的鱼的一些肾小管上皮细胞肥大和空泡化。在暴露90天的HgCl2组中观察到了再生现象。然而，暴露180天后，所有组的肾脏组织学看起来都正常。
