Banerjee T K, Paul V I
Department of Zoology, Banaras Hindu University, Varanas, India.
Biomed Environ Sci. 1993 Mar;6(1):45-58.
The toxicity of 4000 ppm (96 h LC50 value) of the inorganic fertilizer ammonium sulphate on the epidermis of Heteropneustes fossilis (H. fossilis) at different intervals of time has been studied. The destruction induced by the ammonium salt is massive. Secretion of a copious amount of slime from the goblet mucous cells leading to the exhaustion and/or shedding and subsequent disappearance is perhaps the first reaction to the toxicity of the irritant. Later, the polygonal epithelial cells of the outermost layer show cyclic stages of necrosis and sloughing followed by their regeneration and repair. The contents of the club cells show enormous shrinkage and condensation with subsequent replacement of their areas with a hazy substance. In the earlier stages of exposure, regeneration takes place quickly, side by side with the degenerative changes at different stages of experimentation. Later after 8 to 10 d, the degenerative changes slow down and the epidermis appears identical to that of the normal skin. Goblet mucous cells also showed several cyclic increases followed by decreases in number and activity.
研究了4000 ppm（96小时半数致死浓度值）的无机肥料硫酸铵在不同时间间隔对印度胡鲶（Heteropneustes fossilis，简称H. fossilis）表皮的毒性。铵盐引起的破坏是巨大的。杯状黏液细胞分泌大量黏液，导致黏液耗尽和/或脱落，随后消失，这可能是对刺激物毒性的第一反应。后来，最外层的多边形上皮细胞呈现出坏死和脱落的循环阶段，随后是再生和修复。棒状细胞的内容物显示出巨大的收缩和凝聚，随后其区域被一种模糊物质取代。在暴露的早期阶段，再生迅速发生，与实验不同阶段的退行性变化同时出现。8至10天后，退行性变化减缓，表皮看起来与正常皮肤相同。杯状黏液细胞的数量和活性也呈现出几次循环性的增加和减少。
