Lin Jimmy, Gan Christine M, Zhang Xiaosong, Jones Siân, Sjöblom Tobias, Wood Laura D, Parsons D Williams, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Parmigiani Giovanni, Velculescu Victor E
Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.
Genome Res. 2007 Sep;17(9):1304-18. doi: 10.1101/gr.6431107. Epub 2007 Aug 10.
A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention.
最近一项对一组乳腺癌和结直肠癌中的大量基因进行的研究，在1149个基因中鉴定出了体细胞突变。为了确定受这些基因影响的潜在生物学过程，我们根据序列相似性、已知功能组和途径中的成员身份以及与其他蛋白质的预测相互作用，研究了它们的假定作用。这些分析确定了在两种肿瘤类型中突变基因富集的功能组和途径。此外，结果还指出了乳腺癌和结直肠癌潜在分子机制的差异，包括各种细胞内信号传导和代谢途径。这些研究提供了一个多维框架，以指导进一步的研究，并有助于确定对恶性进展和治疗干预至关重要的细胞过程。
