Casero Robert A, Marton Laurence J
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Nat Rev Drug Discov. 2007 May;6(5):373-90. doi: 10.1038/nrd2243.
The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.
多胺亚精胺和精胺及其二胺前体腐胺是天然存在的聚阳离子烷基胺，对真核细胞生长至关重要。在癌症和其他过度增殖性疾病中，对多胺的需求及其代谢常常失调，因此使多胺功能和代谢成为治疗干预的有吸引力的靶点。我们对多胺功能、代谢调节以及正常细胞与肿瘤细胞在多胺生物学方面差异的理解取得的最新进展，增强了对这条富含靶点的药物开发途径的兴趣。
