Faculty of Chemistry, Alexandru Ioan Cuza University, 11 Carol I Blvd., 700506 Iasi, Romania.
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Sachi" Technical University, 73 Professor Dimitrie Mangeron Blvd., 700050 Iasi, Romania.
Int J Mol Sci. 2021 Nov 9;22(22):12139. doi: 10.3390/ijms222212139.
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against .
原始结果在研究领域呈现,该研究领域涉及通过磺酸基扩展酰基硫代缩氨基脲固定在 5-硝基苯并咪唑结构上的残留物的反应。研究的目的是增加新的硫代缩氨基脲衍生物在生物化学领域的应用潜力,具有广泛的医学应用。新获得的化合物通过元素分析和光谱分析(FT-IR 和 H NMR)进行了表征。还进行了关于化学反应优化的研究。进行的体外生物学测试证实了三种新获得的化合物对 的抗结核活性。