Institute of Pharmacology and Toxicology at the RWTH Aachen, Wendlingweg, 52049, Aachen, Germany.
Inflammopharmacology. 1998;6(2):159-78. doi: 10.1007/s10787-998-0032-2.
The influence of human atrial natriuretic peptide (ANP) and of two related peptides, human brain natriuretic peptide (BNP) and urodilatin (URO) on the bronchoconstriction induced by inhalation of histamine in conscious, non-anaesthetized guinea pigs was tested.Changes in lung function were registered using two independent methods, one operating in a closed body-plethysmographic system, the other in an open system based on the time lag of air flow curves. The peptides were infused (0.25 ml/min) into the jugular vein for a period from 10 min before until 15 min after the histamine inhalation.ANP displayed virtually no effect on the bronchoconstriction. URO showed some inibition at 1280ng kg(-1) min(-1), but not at lower doses. BNP (640ng kg(-1) min(-1)) inhibited the bronchoconstriction markedly for the total registration period.It can be concluded from these results that BNP exerts bronchoprotective effects in the conscious guinea pig, which are superior to those of ANP or URO.
研究了人心房利钠肽（ANP）和两种相关肽，人心脑利钠肽（BNP）和尿利肽（URO）对清醒非麻醉豚鼠吸入组胺引起的支气管收缩的影响。使用两种独立的方法记录肺功能变化，一种在封闭的体腔描记系统中运行，另一种基于气流曲线的时间滞后的开放系统。肽在组胺吸入前 10 分钟至后 15 分钟内以 0.25 ml/min 的速度注入颈静脉。
ANP 对支气管收缩几乎没有影响。URO 在 1280ng kg(-1) min(-1) 时表现出一定的抑制作用，但在较低剂量时没有。BNP（640ng kg(-1) min(-1)）显著抑制支气管收缩整个记录期。
从这些结果可以得出结论，BNP 在清醒的豚鼠中发挥支气管保护作用，优于 ANP 或 URO。
