Buffet C, Sinico M, Adda G, Fabre M, Roge J, Pelletier G, Martin E, Etienne J P
Service de Gastroentérologie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
Gastroenterol Clin Biol. 1991;15(11):856-8.
We report two cases of nodular regenerative hyperplasia of the liver associated with primary biliary cirrhosis. Cholestasis and presence of antimitochondrial antibodies were noted in both patients. In one patient, the diagnosis of nodular regenerative hyperplasia was supported by the demonstration of disseminated small hepatic nodules without perinodular fibrosis. Twelve years later, the histopathological picture was one of primary biliary cirrhosis. The other patient presented an histological picture of regenerative hyperplasia of the liver and primary biliary cirrhosis. The association of regenerative hyperplasia of the liver and primary biliary cirrhosis is discussed.
我们报告两例与原发性胆汁性肝硬化相关的肝脏结节性再生性增生病例。两名患者均出现胆汁淤积及抗线粒体抗体阳性。其中一名患者,通过显示弥漫性小肝结节且无结节周围纤维化,支持了结节性再生性增生的诊断。十二年后,组织病理学表现为原发性胆汁性肝硬化。另一名患者呈现出肝脏再生性增生和原发性胆汁性肝硬化的组织学表现。本文讨论了肝脏再生性增生与原发性胆汁性肝硬化的关联。