Opakunle W O, Spring M S
J Pharm Pharmacol. 1977 May;29(5):298-302. doi: 10.1111/j.2042-7158.1977.tb11316.x.
Boric acid, sulphanilamide and citric acid have been mixed separately with lactose and then granulated by massing and screening. The granules have been fractionated by sieving and each fraction has been analysed for lactose content. The effect of premixing time, massing time, binder volume and ratio of components on the distribution of lactose between size fractions of granules prepared from lactose: boric acid mixtures has been investigated. Uneven distribution of lactose has been found for all blends examined. There is a premixing time and massing time that gives the optimum distribution of lactose for any given blend and binder volume. Increased binder volume in some cases improves granule uniformity. The proportion of lactose in the blend has a major effect on the distribution of this component in the granules, as does the particle size of the lactose. Granules prepared from blends of lactose with sulphanilamide and with citric acid were also examined for lactose distribution.
硼酸、磺胺和柠檬酸已分别与乳糖混合，然后通过捏合和筛选制粒。颗粒通过筛分进行分级，每个级分都进行了乳糖含量分析。研究了预混时间、捏合时间、粘合剂体积以及组分比例对由乳糖：硼酸混合物制备的颗粒大小级分之间乳糖分布的影响。在所检查的所有混合物中均发现乳糖分布不均匀。对于任何给定的混合物和粘合剂体积，都存在一个能使乳糖分布达到最佳的预混时间和捏合时间。在某些情况下，增加粘合剂体积可提高颗粒均匀性。混合物中乳糖的比例对该组分在颗粒中的分布有重大影响，乳糖的粒径也是如此。还对由乳糖与磺胺以及与柠檬酸的混合物制备的颗粒进行了乳糖分布检查。
