Wikberg M, Alderborn G
Department of Pharmaceutics, Uppsala Biomedical Center, Uppsala University, Sweden.
Pharm Res. 1993 Jan;10(1):88-94. doi: 10.1023/a:1018929214629.
Two sets of lactose-polyvinylpyrrolidone granulations (95:5) of different intragranular binder distributions were produced. The intragranular binder distribution was controlled by a two-step granulation procedure. The compactibility as well as the volume reduction behavior of the granulations was evaluated. Granulations with a more homogeneous distribution of binder in the granules generally produced tablets of a higher mechanical strength than granulations with a peripheral localization of binder. The tablet strength of the latter granulations was also comparatively more reduced by the addition of magnesium stearate. Thus, it is suggested that high granule porosity in combination with homogeneous intragranular binder distribution is advantageous for the compactibility of a granulation. The results of this study therefore contradict earlier suggestions in the literature regarding the preferred intragranular binder distribution.
制备了两组具有不同颗粒内粘合剂分布的乳糖-聚乙烯吡咯烷酮颗粒（95:5）。颗粒内粘合剂分布通过两步制粒程序进行控制。对颗粒的可压性以及体积减小行为进行了评估。与粘合剂位于颗粒周边的颗粒相比，粘合剂在颗粒中分布更均匀的颗粒通常能制得机械强度更高的片剂。添加硬脂酸镁后，后一种颗粒的片剂强度相对降低得更多。因此，有人提出，高颗粒孔隙率与颗粒内粘合剂均匀分布相结合有利于颗粒的可压性。因此，本研究结果与文献中关于颗粒内粘合剂分布偏好的早期观点相矛盾。
