口腔癌前病变和恶性病变中DARPP-32表达降低。
Decreased expression of DARPP-32 in oral premalignant and malignant lesions.
作者信息
Pimenta Flávio Juliano, Horta Martinho Campolina Rebello, Vidigal Paula Vieira, De Souza Bruno Rezende, De Marco Luiz, Romano-Silva Marco Aurélio, Gomez Ricardo Santiago
机构信息
Departments of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
Anticancer Res. 2007 Jul-Aug;27(4B):2339-43.
BACKGROUND
DARPP-32 is a neuronal protein that plays a central role in dopaminergic neurotransmission. Although DARPP-32 may contribute to the pathogenesis of several human malignancies, its expression has never been investigated in oral premalignant and malignant lesions.
MATERIALS AND METHODS
DARPP-32 expression was examined using immunohistochemistry in 14 normal oral mucosa, 5 normal lower lip mucosa, 41 oral leukoplakia (OL), 30 oral squamous cell carcinoma (OSCC) and 20 lower lip squamous cell carcinoma (LLSCC) specimens. Differences of its expression between groups were analyzed.
RESULTS
OSCC and OL with moderate or severe dysplasia showed lower DARPP-32 expression in relation to normal oral mucosa. LLSCC showed lower DARPP-32 expression than normal lower lip mucosa and OSSC.
CONCLUSION
The decreased expression of DARPP-32 in oral premalignant and malignant lesions suggests a tumor suppressor role for this protein in the tumorigenesis of these lesions.
背景
DARPP - 32是一种在多巴胺能神经传递中起核心作用的神经元蛋白。尽管DARPP - 32可能参与多种人类恶性肿瘤的发病机制，但其在口腔癌前病变和恶性病变中的表达从未被研究过。
材料与方法
采用免疫组织化学方法检测了14例正常口腔黏膜、5例正常下唇黏膜、41例口腔白斑（OL）、30例口腔鳞状细胞癌（OSCC）和20例下唇鳞状细胞癌（LLSCC）标本中DARPP - 32的表达。分析了各组之间其表达的差异。
结果
与正常口腔黏膜相比，中度或重度发育异常的OSCC和OL显示出较低的DARPP - 32表达。LLSCC显示出比正常下唇黏膜和OSCC更低的DARPP - 32表达。
结论
DARPP - 32在口腔癌前病变和恶性病变中的表达降低表明该蛋白在这些病变的肿瘤发生中具有肿瘤抑制作用。
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