Unità di Medicina e Patologia Orale, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20142 Milan, Italy.
Oral Dis. 2010 Jan;16(1):61-7. doi: 10.1111/j.1601-0825.2009.01614.x. Epub 2009 Aug 28.
Survivin is involved in modulation of cell death and cell division processes. Survivin expression in normal adult tissues has not been fully understood, although it is markedly lower than in cancer, where it is over-expressed.
To investigate survivin expression in normal, potentially malignant and cancerous oral mucosa.
We measured survivin mRNA levels by real-time RT-PCR in specimens of oral mucosa (15 from normal mucosa, 17 from potentially malignant lesions, 17 from neoplasms). Scores were compared using Kruskal-Wallis test and post hoc according to Conover. Chi-squared test was used for dichotomous data.
The median relative levels of survivin mRNA resulted six for normal mucosa, eight for potentially malignant lesions, 13 for cancers: differences among these three groups were statistically significant, as between cancer and potentially malignant lesions. Expression in normal mucosa and potentially lesions group showed no significant difference. Low, but not marginal expression of survivin in normal mucosa is a new finding, and it could be explained with the higher sensibility of our methods.
Survivin expression in oral potentially malignant lesions might indicate a progressive deregulation of expression paralleling oncogenesis, particularly during the first stages of process, suggesting a putative predictive role for survivin.
Survivin 参与细胞死亡和细胞分裂过程的调节。尽管 Survivin 在癌症中过度表达，但正常成年组织中的表达尚未完全理解，其表达水平明显低于癌症。
研究 Survivin 在正常、潜在恶性和癌性口腔黏膜中的表达。
我们通过实时 RT-PCR 测量了口腔黏膜标本中的 Survivin mRNA 水平（正常黏膜 15 例，潜在恶性病变 17 例，肿瘤 17 例）。使用 Kruskal-Wallis 检验和 Conover 后检验比较评分。二项数据采用卡方检验。
Survivin mRNA 的中位相对水平分别为正常黏膜 6，潜在恶性病变 8，癌症 13：三组间差异有统计学意义，癌症与潜在恶性病变间差异亦有统计学意义。正常黏膜和潜在病变组的表达无显著差异。在正常黏膜中低但非边缘表达 Survivin 是一个新发现，这可以用我们方法的更高灵敏度来解释。
口腔潜在恶性病变中 Survivin 的表达可能表明表达的逐渐失调与癌变平行，特别是在该过程的早期阶段，提示 Survivin 具有潜在的预测作用。
