Lavialle C, Suarez H G, Morris A G, Estrade S, Stévenet J, Cassingena R
Arch Virol. 1976;50(1-2):137-46. doi: 10.1007/BF01318008.
Throughout in vitro passages, Chinese hamster kidney (CHK) cells progressively lost susceptibility to SV 40 virus infection while remaining continuously susceptible to viral DNA infection. Upon infection with SV 40 virus or viral DNA, the CHK cell line supported viral DNA and virus replication at a low level. SV 40 transformed CHK cell lines spontaneously produced small amounts of viral DNA and virions. The percentage of virus-producing cells was low. Various clones derived from each of these lines behaved as the parental cell population, leading to the conclusion that each CHK cell, whether transformed or not with SV 40, is potentially permissive for this virus.
在整个体外传代过程中,中国仓鼠肾(CHK)细胞对SV 40病毒感染的敏感性逐渐丧失,而对病毒DNA感染仍持续敏感。用SV 40病毒或病毒DNA感染后,CHK细胞系能在低水平上支持病毒DNA和病毒复制。SV 40转化的CHK细胞系自发产生少量病毒DNA和病毒粒子。产生病毒的细胞百分比很低。从这些细胞系中衍生出的各种克隆的行为与亲代细胞群体相同,从而得出结论:每个CHK细胞,无论是否被SV 40转化,对这种病毒都可能是允许的。