Bhattacharjee Pradip, Glusac Earl J
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
J Cutan Pathol. 2007 Sep;34(9):716-20. doi: 10.1111/j.1600-0560.2006.00723.x.
In the absence of mites, the histologic diagnosis of human scabies can be difficult. Scabies can mimic a variety of inflammatory and lymphoproliferative disorders. It is under-recognized that scabies can also mimic Langerhans cell histiocytosis.
Sixteen examples of scabies were reviewed histologically and immunohistochemically (CD1a, CD3, CD20, CD30 and S100).
Immunohistochemical labeling showed florid CD1a and S100 positivity in most cases, indicative of Langerhans cell hyperplasia. Scattered CD30+ lymphocytes were also typically present, within a dense infiltrate, primarily composed of T lymphocytes and eosinophils.
Because of the prominent CD1a+/S100+ component, scabies can mimic Langerhans cell histiocytosis. This finding should be considered in conjunction with scattered CD30+ cells and clinical features to avoid misdiagnosis.
在没有螨虫的情况下，人类疥疮的组织学诊断可能会很困难。疥疮可模仿多种炎症性和淋巴增殖性疾病。人们尚未充分认识到疥疮也可模仿朗格汉斯细胞组织细胞增多症。
对16例疥疮病例进行了组织学和免疫组织化学检查（CD1a、CD3、CD20、CD30和S100）。
免疫组织化学标记显示，大多数病例中CD1a和S100呈强阳性，提示朗格汉斯细胞增生。在主要由T淋巴细胞和嗜酸性粒细胞组成的密集浸润内，通常也可见散在的CD30+淋巴细胞。
由于存在显著的CD1a+/S100+成分，疥疮可模仿朗格汉斯细胞组织细胞增多症。应结合散在的CD30+细胞和临床特征考虑这一发现，以避免误诊。
