Wang Sheng-Lan, Li Shau-Hsuan, Chen Wan-Tzu, Chai Chee-Yin
Department of Pathology, Faculty of Medicine, Kaohsiung Medical University, and Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.
APMIS. 2007 Aug;115(8):906-10. doi: 10.1111/j.1600-0463.2007.apm_653.x.
The clinical pathologic criteria for nuclear features of papillary thyroid carcinoma are subjective and sometimes cannot distinguish carcinoma from adenomatous goiter and follicular neoplasms. No single antibody has demonstrated high sensitivity or specificity in making these distinctions. Using quantitative analysis of immunohistochemical staining with D2-40, a recently available monoclonal antibody used as a lymphatic endothelial marker, we examined 72 cases of papillary carcinoma. Controls included 36 follicular adenomas, 36 follicular carcinomas, and 20 adenomatous goiters with papillary hyperplasia. Cytoplasmic D2-40 immunoreactivity was present in 60 of 72 papillary carcinomas, 2 cases of follicular adenoma and 2 cases of follicular carcinoma, whereas no adenomatous goiter or normal thyroid glands contained positive epithelial cells. Overexpression of D2-40 in papillary thyroid carcinomas thus has potential diagnostic utility in differentiating these tumors from their potential histologic mimics.
甲状腺乳头状癌核特征的临床病理标准具有主观性，有时无法将癌与腺瘤性甲状腺肿及滤泡性肿瘤区分开来。在进行这些区分时，没有一种单一抗体表现出高敏感性或特异性。我们使用D2-40免疫组织化学染色的定量分析方法，D2-40是一种最近可用的用作淋巴管内皮标志物的单克隆抗体，对72例乳头状癌进行了检测。对照组包括36例滤泡性腺瘤、36例滤泡性癌和20例伴有乳头状增生的腺瘤性甲状腺肿。72例乳头状癌中有60例、2例滤泡性腺瘤和2例滤泡性癌存在细胞质D2-40免疫反应性，而腺瘤性甲状腺肿或正常甲状腺中均未发现阳性上皮细胞。因此，D2-40在甲状腺乳头状癌中的过表达在将这些肿瘤与其潜在的组织学相似物区分开来方面具有潜在的诊断效用。
