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[孕酮对不同形态子宫内膜癌碳水化合物代谢酶影响的组织化学研究]

[A histochemical study of the effect of progesterone on the carbohydrate metabolism enzymes of different morphologic forms of endometrial cancer].

作者信息

Prianishnikov V A, Bokhman Ia V, Chepik O F

出版信息

Arkh Patol. 1975;37(6):19-23.

PMID:176978
Abstract

The histochemical method was used for determining glycogen, phosphorylase, glycogensynthetase, and glucose-6-phosphatase in order to evaluate the effect of progesterone on different morphological forms of cancer of the endometrium in man. On the basis of histochemical analysis of changes in the carbohydrate metabolism in 29 cases of cancer before and after treatment with progesterone a conclusion is drawn that sensitivity of tumours of the endometrium to hormonotherapy only partially depends upon the degree of their morphological differentiation.

摘要

采用组织化学方法测定糖原、磷酸化酶、糖原合成酶和葡萄糖-6-磷酸酶,以评估孕酮对人类子宫内膜癌不同形态学类型的影响。基于对29例子宫内膜癌患者在孕酮治疗前后碳水化合物代谢变化的组织化学分析,得出结论:子宫内膜肿瘤对激素治疗的敏感性仅部分取决于其形态学分化程度。

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