Vila-Córcoles Angel, Rodriguez Teresa, de Diego Cinta, Ochoa Olga, Valdivieso Amparo, Salsench Elisabet, Ansa Xabier, Badía Waleska, Saún Neus
Primary Care Service of Tarragona-Valls, Institut Català de la Salut, Tarragona, Spain.
Vaccine. 2007 Sep 17;25(37-38):6699-707. doi: 10.1016/j.vaccine.2007.07.015. Epub 2007 Jul 27.
This study assessed the relationship between the reception of conventional inactivated influenza vaccine and winter mortality in a prospective cohort that included 11,240 Spanish community-dwelling elderly individuals followed from January 2002 to April 2005. Annual influenza vaccine status was a time-varying condition and primary outcome was all-cause death during study period. Multivariable Cox proportional-hazard models adjusted by age, sex and co-morbidity were used to evaluate vaccine effectiveness. Influenza vaccination was associated with a significant reduction of 23% in winter mortality risk during overall influenza periods. The attributable mortality risk in non-vaccinated people was 24 deaths per 100,000 persons-week within influenza periods, the prevented fraction for the population was 14%, and one death was prevented for every 239 annual vaccinations (ranging from 144 in Winter 2005 to 1748 in Winter 2002).
本研究在一个前瞻性队列中评估了常规灭活流感疫苗接种与冬季死亡率之间的关系，该队列包括11240名居住在西班牙社区的老年人，随访时间为2002年1月至2005年4月。年度流感疫苗接种状况是一个随时间变化的条件，主要结局是研究期间的全因死亡。采用经年龄、性别和合并症调整的多变量Cox比例风险模型来评估疫苗效力。在整个流感流行期间，流感疫苗接种与冬季死亡风险显著降低23%相关。在流感流行期间，未接种疫苗人群的可归因死亡风险为每100000人周24例死亡，人群的预防率为14%，每239次年度接种可预防1例死亡（范围从2005年冬季的144例到2002年冬季的1748例）。
