MN1，人类急性髓系白血病中的一个新角色。
MN1, a novel player in human AML.
作者信息
Grosveld Gerard C
机构信息
Department of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
出版信息
Blood Cells Mol Dis. 2007 Nov-Dec;39(3):336-9. doi: 10.1016/j.bcmd.2007.06.009. Epub 2007 Aug 14.
Abstract
The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain types of human acute myeloid leukemia. Upregulation is invariantly associated with inv(16) AML but is also found in other AML subtypes. Overexpression of this gene is also associated with a worse prognosis and a shorter survival in AML patients with a normal karyotype. In this short review, I will discuss the role of MN1 in myeloid leukemia.
摘要
转录共激活因子MN1已被鉴定为在某些类型的人类急性髓系白血病中过表达的基因。上调始终与inv(16)急性髓系白血病相关，但在其他急性髓系白血病亚型中也有发现。该基因的过表达还与核型正常的急性髓系白血病患者预后较差和生存期较短有关。在这篇简短的综述中，我将讨论MN1在髓系白血病中的作用。
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本文引用的文献
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Leukemia. 2007 Aug;21(8):1679-90. doi: 10.1038/sj.leu.2404778. Epub 2007 May 24.
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MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.MN1过表达可诱导小鼠发生急性髓系白血病，并可预测急性髓系白血病患者对全反式维甲酸的耐药性。
Blood. 2007 Sep 1;110(5):1639-47. doi: 10.1182/blood-2007-03-080523. Epub 2007 May 9.
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9
MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice.在多能祖细胞中表达的MN1-TEL髓系癌蛋白扰乱髓系和淋巴系生长，并在小鼠中引发T淋巴细胞肿瘤。
Blood. 2005 Dec 15;106(13):4278-86. doi: 10.1182/blood-2005-04-1674. Epub 2005 Aug 4.
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