甘丙肽信息相关肽可抑制白色念珠菌的生长及其从出芽形式向菌丝形式的转变。
Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans.
作者信息
Rauch Isabella, Lundström Linda, Hell Markus, Sperl Wolfgang, Kofler Barbara
机构信息
Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
出版信息
Antimicrob Agents Chemother. 2007 Nov;51(11):4167-70. doi: 10.1128/AAC.00166-07. Epub 2007 Aug 13.
Abstract
The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system.
摘要
人角质形成细胞中编码甘丙肽信息相关肽（GMAP）的mRNA表达，会因脂多糖和白色念珠菌暴露而上调。GMAP对白色念珠菌具有生长抑制活性，并抑制芽生形式向菌丝形式的转变，这表明GMAP可能是固有免疫系统的一个新组成部分。
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