Li Zhongjie, Jing Xiaoyuan, Yuan Yaping, Shui Yingbin, Li Shasha, Zhao Zhuoran, Deng Bo, Zhang Wenlu
School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang, China.
Front Microbiol. 2022 May 11;13:862834. doi: 10.3389/fmicb.2022.862834. eCollection 2022.
The increase in the occurrence of antifungal-resistant infections necessitates more research to explore alternative effective and safe agents against this fungus. In this work, Phibilin, a new antimicrobial peptide obtained from and used in traditional Chinese medicine, effectively inhibits the growth and activities of , including the clinical resistant strains. Phibilin is a fungicidal antimicrobial peptide that exhibited its antimicrobial effect against mainly by disrupting the membrane and interacting with the DNA of the fungi. In particular, Phibilin induces the necrosis of the ROS-related pathway. Moreover, this antifungal compound inhibited the biofilm formation of by preventing the development of hyphae in a dose-dependent manner. Furthermore, Phibilin and clotrimazole displayed a synergistic effect in inhibiting the growth of the fungi. In the mouse cutaneous infection model, Phibilin significantly inhibited the formation of skin abscesses and decreased the counts of cells in the infected area. Overall, Phibilin is potentially an effective agent against skin infections caused by .
抗真菌耐药感染发生率的增加使得有必要开展更多研究，以探索针对这种真菌的其他有效且安全的药物。在这项研究中，菲比林是一种从中药中获得并用于传统中药的新型抗菌肽，它能有效抑制包括临床耐药菌株在内的[具体真菌名称未给出]的生长和活性。菲比林是一种杀菌性抗菌肽，其对[具体真菌名称未给出]的抗菌作用主要通过破坏细胞膜以及与真菌的DNA相互作用来实现。特别是，菲比林通过ROS相关途径诱导[具体真菌名称未给出]的坏死。此外，这种抗真菌化合物通过以剂量依赖的方式阻止菌丝的发育来抑制[具体真菌名称未给出]生物膜的形成。此外，菲比林和克霉唑在抑制真菌生长方面表现出协同作用。在小鼠皮肤感染模型中，菲比林显著抑制皮肤脓肿的形成，并减少感染区域的[具体细胞名称未给出]细胞数量。总体而言，菲比林可能是一种针对由[具体真菌名称未给出]引起的皮肤感染的有效药物。
