Müller M, Ott H, Bruns V
Zoologisches Institut, J.W. Goethe-Universität, Frankfurt am Main, F.R.G.
Hear Res. 1991 Nov;56(1-2):191-6. doi: 10.1016/0378-5955(91)90169-a.
The tonotopic map of the cochlea in the gerbil Pachyuromys duprasi was analysed by local iontophoretic HRP-application into physiologically defined regions of the cochlear nucleus and mapping of subsequent HRP transport patterns in cochlear spiral ganglion cells. Furthermore the spiral ganglion cell density along the cochlear duct was determined. The cochlear tonotopic map was established in the frequency range between 0.6 and 17.5 kHz. These frequencies corresponded to locations between 86 and 3% basilar membrane length (0% = cochlear base). It was found that the slope of the place-frequency map varied with frequency, the maximum slope being found between 1 and 4 kHz. This frequency range corresponds to the frequency range of highest auditory sensitivity as determined from cochlear microphonic recordings (Plassmann et al., 1987). The density of spiral ganglion cells also varied along the cochlear duct. A pronounced maximum (1927 cells/mm) was located at around 70% basilar membrane length, compared to values of 800 cell per mm near the cochlear apex and base. This region of high ganglion cell density also corresponds to the frequency range of highest auditory sensitivity.
通过将局部离子电渗 HRP 应用于沙鼠粗尾鼠耳蝠耳蜗核的生理定义区域，并绘制耳蜗螺旋神经节细胞中随后的 HRP 运输模式，分析了耳蜗的音频拓扑图。此外，还确定了沿耳蜗管的螺旋神经节细胞密度。在 0.6 至 17.5 kHz 的频率范围内建立了耳蜗音频拓扑图。这些频率对应于基底膜长度的 86% 至 3% 之间的位置（0% = 耳蜗底部）。研究发现，位置 - 频率图的斜率随频率变化，最大斜率出现在 1 至 4 kHz 之间。该频率范围对应于根据耳蜗微音器记录确定的最高听觉敏感度的频率范围（Plassmann 等人，1987 年）。螺旋神经节细胞的密度也沿耳蜗管变化。在基底膜长度约 70% 处有一个明显的最大值（1927 个细胞/mm），而在耳蜗顶部和底部附近的值为 800 个细胞/mm。这个高神经节细胞密度区域也对应于最高听觉敏感度的频率范围。
