Carvalho-Braga D, Almeida R, Azevedo M, Amaral I, Medina J, Hargreaves M
Department of Endocrinology, Oporto Medical School, Hospital de S. João, Portugal.
J Diabet Complications. 1991 Apr-Sep;5(2-3):126-7. doi: 10.1016/0891-6632(91)90042-n.
Glomerular hyperfiltration is a characteristic functional abnormality in insulin-dependent diabetes mellitus (IDDM) patients, but the underlying mechanisms remain controversial. Supine and ambulant plasma renin activity (PRA) and aldosterone were measured in ten IDDM patients with normal glomerular filtration rate (GFR), in ten IDDM patients with elevated GFR and in ten nondiabetic controls. Basal and stimulated PRA or aldosterone did not differ significantly between the three groups. These results suggest that in insulin-dependent diabetes the glomerular hyperfiltration is not causally related to hyperactivity of the renin-angiotensin-aldosterone system.
肾小球高滤过是胰岛素依赖型糖尿病（IDDM）患者的一种特征性功能异常，但其潜在机制仍存在争议。对10名肾小球滤过率（GFR）正常的IDDM患者、10名GFR升高的IDDM患者和10名非糖尿病对照者测量了仰卧位和活动时的血浆肾素活性（PRA）及醛固酮。三组之间基础及刺激后的PRA或醛固酮无显著差异。这些结果提示，在胰岛素依赖型糖尿病中，肾小球高滤过与肾素-血管紧张素-醛固酮系统的活性增高无因果关系。
