Hara S, Arizono K, Ubara Y, Morita T, Suzuki Y, Ogura Y, Hagura R, Akanuma Y
Kidney Center, Toranomon Hospital, Tokyo, Japan.
J Diabet Complications. 1991 Apr-Sep;5(2-3):131-3. doi: 10.1016/0891-6632(91)90044-p.
Risk factors for retardation of renal function in 22 patients with non-insulin-dependent diabetes mellitus (NIDDM) were studied and compared with those in 16 patients with insulin-dependent diabetes mellitus (IDDM). The annual decline rate of reciprocal serum creatinine was calculated from the rise of creatinine to the commencement of dialysis. The annual decline rate was compared with levels of blood pressure, fasting blood glucose, HbA1, and lipids, and clinical findings in patients with or without nephrotic syndrome during the same period. There was no significant difference in the rate of decline in levels of fasting blood glucose and HbA1, in IDDM and NIDDM. In NIDDM, the major risk factor is hypertension, as in IDDM. Triglycerides and total cholesterol also play roles in the retardation of renal function. Nephrotic syndrome also influenced the retardation of renal function in both IDDM and NIDDM.
对22例非胰岛素依赖型糖尿病（NIDDM）患者肾功能减退的危险因素进行了研究，并与16例胰岛素依赖型糖尿病（IDDM）患者的危险因素进行了比较。从肌酐升高到开始透析计算血清肌酐倒数的年下降率。将年下降率与血压、空腹血糖、糖化血红蛋白（HbA1）和血脂水平以及同期有或无肾病综合征患者的临床 findings 进行比较。IDDM和NIDDM患者空腹血糖和HbA1水平的下降率无显著差异。在NIDDM中，主要危险因素与IDDM一样是高血压。甘油三酯和总胆固醇也在肾功能减退中起作用。肾病综合征也影响IDDM和NIDDM患者的肾功能减退。
