Nakamura H, Yamazaki M, Chiba Y, Tani N, Momotsu T, Kamoi K, Ito S, Yamaji T, Shibata A
First Department of Internal Medicine, Niigata University School of Medicine, Japan.
J Diabet Complications. 1991 Apr-Sep;5(2-3):140-2. doi: 10.1016/0891-6632(91)90048-t.
To evaluate the effects of protein loading on glomerular filtration rate (GFR), urinary excretion rate of albumin (AER), and plasma concentration of amino acids, 10 healthy volunteers and six diabetics were studied before and after eating tuna fish, egg white, cheese, or tofu. Furthermore, to study the possible role of glucagon, growth hormone (GH), atrial natriuretic peptide (ANP), or kallikrein in the responses of GFR, these substances were measured before and after protein loading. GFR increased significantly (p less than .001) after ingestion of tuna fish. No significant differences were seen between the GFR before and that after ingestion of the other foods. AER was unchanged following protein loading. Plasma concentrations of alanine, glycine, and arginine increased to a greater degree after ingestion of tuna fish than after digestion of the other foods. This result suggests that the response of GFR after protein loading may differ from one protein to another, and that these responses may not be directly mediated by glucagon, GH, ANP, or kallikrein.
为评估蛋白质负荷对肾小球滤过率（GFR）、白蛋白尿排泄率（AER）及血浆氨基酸浓度的影响，对10名健康志愿者和6名糖尿病患者在食用金枪鱼、蛋清、奶酪或豆腐前后进行了研究。此外，为研究胰高血糖素、生长激素（GH）、心房利钠肽（ANP）或激肽释放酶在GFR反应中的可能作用，在蛋白质负荷前后对这些物质进行了测量。摄入金枪鱼后GFR显著升高（p＜0.001）。摄入其他食物前后的GFR未见显著差异。蛋白质负荷后AER未改变。摄入金枪鱼后，血浆丙氨酸、甘氨酸和精氨酸浓度的升高程度大于摄入其他食物后。该结果表明，蛋白质负荷后GFR的反应可能因蛋白质种类而异，且这些反应可能并非由胰高血糖素、GH、ANP或激肽释放酶直接介导。
