Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Duke Diet and Fitness Center, Duke University Health System, Durham, North Carolina.
Ann N Y Acad Sci. 2020 Feb;1461(1):25-36. doi: 10.1111/nyas.13997. Epub 2019 Jan 15.
Diabetes mellitus and obesity both contribute to chronic kidney disease (CKD) and diabetic kidney disease (DKD), and they can accelerate the loss of kidney function. Dietary intake can potentially have wide-reaching effects on the risk of CKD/DKD and their progression by reducing weight and blood pressure, improving glycemic control, reducing hyperfiltration, and modulating inflammation. Low-carbohydrate (LC) diets can reduce weight and improve glycemic control, but the relatively higher protein content also raises concern in CKD/DKD. Empiric evidence supporting the kidney-related benefits or risks of LC diets is needed to understand the balance of these potential harms and benefits for patients with DKD and is the subject of our review.
糖尿病和肥胖均可导致慢性肾脏病（CKD）和糖尿病肾病（DKD），并加速肾功能丧失。饮食摄入通过减轻体重和降低血压、改善血糖控制、减少超滤以及调节炎症等方式，可能对 CKD/DKD 的发病风险及其进展产生广泛影响。低碳水化合物（LC）饮食可减轻体重并改善血糖控制，但相对较高的蛋白质含量也引起了人们对 CKD/DKD 的关注。需要获得支持 LC 饮食与肾脏相关获益或风险的经验证据，以了解 DKD 患者的潜在危害和获益之间的平衡，这也是我们本次综述的主题。
