Kartal Elif Doyuk, Alpat Saygn Nayman, Ozgunes Ilhan, Usluer Gaye
Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
Eur J Gastroenterol Hepatol. 2007 Sep;19(9):817-20. doi: 10.1097/MEG.0b013e32818b27e5.
Combined treatment with pegylated interferon (PEG-IFN) and ribavirin is currently recommended for the treatment of chronic hepatitis C virus (HCV) infection. Many side effects including hair disorders have, however, been reported related to this treatment. Alopecia universalis is a severe form of hair disorder. Three cases of alopecia universalis during PEG-IFN and ribavirin combination therapy have been reported in the literature. Herein is reported a case of reversible alopecia universalis, with complete hair loss extending to the whole body, secondary to PEG-IFN alpha-2b and ribavirin combination therapy for chronic HCV infection. Hair regrowth began within 3 months of the completion of combined therapy. In case the liver disease is advanced, and virologic response occurs, treatment can still be completed, as it appears that these side effects are reversible.
目前推荐聚乙二醇干扰素（PEG - IFN）和利巴韦林联合治疗慢性丙型肝炎病毒（HCV）感染。然而，已经报道了许多与这种治疗相关的副作用，包括毛发疾病。全秃是一种严重的毛发疾病形式。文献中报道了3例在PEG - IFN和利巴韦林联合治疗期间发生全秃的病例。本文报道了1例继发于PEG - IFNα - 2b和利巴韦林联合治疗慢性HCV感染的可逆性全秃病例，脱发完全累及全身。联合治疗结束后3个月内开始重新生发。如果肝病进展且出现病毒学应答，治疗仍可完成，因为这些副作用似乎是可逆的。
