Grossmann Soraya de Mattos Camargo, Teixeira Rosângela, de Aguiar Maria Cássia Ferreira, do Carmo Maria Auxiliadora Vieira
Department of Oral Surgery and Pathology, School of Dentistry, Viral Hepatitis Ambulatory, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Eur J Gastroenterol Hepatol. 2008 Jul;20(7):702-6. doi: 10.1097/MEG.0b013e3282f1cc5d.
It is estimated that 170-200 million people in the world are chronically infected with the hepatitis C virus. This fact indicates that the prevention and treatment of hepatitis C virus infection are a priority in public health care. To date, the best treatment consists of the combination of pegylated interferon (IFN) and ribavirin. IFN is costly and associated with low tolerance and severe side effects. Ribavirin is also problematic because it causes secondary anemia in most patients. It has been described that oral lichen planus (OLP) can appear or be exacerbated during the treatment of chronic hepatitis C. The improvement of the lesions of OLP after the discontinuation of therapy suggests that IFN may induce or worsen these lesions in some patients. This study examines three cases of exacerbation of OLP during the treatment of chronic hepatitis C with pegylated IFN and ribavirin.
据估计，全球有1.7亿至2亿人长期感染丙型肝炎病毒。这一事实表明，丙型肝炎病毒感染的预防和治疗是公共卫生保健的优先事项。迄今为止，最佳治疗方案是聚乙二醇化干扰素（IFN）和利巴韦林联合使用。IFN成本高昂，耐受性低且副作用严重。利巴韦林也存在问题，因为它会使大多数患者出现继发性贫血。据描述，在慢性丙型肝炎治疗期间，口腔扁平苔藓（OLP）可能会出现或加重。治疗中断后OLP病变的改善表明，IFN可能会在某些患者中诱发或加重这些病变。本研究考察了3例在使用聚乙二醇化IFN和利巴韦林治疗慢性丙型肝炎期间OLP加重的病例。
