Basu Sriparna, Chatterjee Mridula, Ganguly Sutapa, Chandra Pranab Kumar
Department of Pediatrics, North Bengal Medical College and Hospital, Sushrutnagar, Darjeeling, India.
J Clin Gastroenterol. 2007 Sep;41(8):756-60. doi: 10.1097/01.mcg.0000248009.47526.ea.
To evaluate the role of Lactobacillus rhamnosus GG (LGG) as probiotic in persistent diarrhea (PD) in children of North Bengal, India.
Hospital-based study.
Randomized, double-blind controlled trial.
All patients of PD admitted over a period of 2 years were included in the study as per predefined inclusion criteria. They were randomized to receive oral rehydration solution (ORS) alone, or ORS plus LGG powder containing 60 million cells, twice daily for a minimum period of 7 days or till diarrhea has stopped along with correction of dehydration with ORS and/or intravenous fluids as per WHO protocol and antibiotics in culture positive patients. The duration and frequency of purge and vomiting were studied. Data were analyzed by SPSS-10 software. Statistical significance was calculated by Student t test and chi2 test.
The study comprised of 235 patients randomized into 2 groups, cases (117) and controls (118). Both the groups were similar with respect to age, number of breastfed infants, presentation with dehydration, degree of protein energy malnutrition, and distribution of infections. Stool culture was positive in 90 (38.3%) patients, Escherichia coli being the commonest organism followed by Shigella spp. and Clostridium difficile. The mean duration of diarrhea was significantly lower in the cases than in controls (5.3 vs. 9.2 d). The average duration of hospital stay was also significantly lesser in cases. No complication was observed from the dose of LGG used.
LGG (dose of 60 million cells) could decrease the frequency and duration of diarrhea and vomiting and reduced hospital stay in patients of PD.
评估鼠李糖乳杆菌GG（LGG）作为益生菌在印度北孟加拉儿童持续性腹泻（PD）中的作用。
基于医院的研究。
随机、双盲对照试验。
根据预先定义的纳入标准，将2年内收治的所有PD患者纳入研究。他们被随机分为两组，一组仅接受口服补液盐（ORS），另一组接受ORS加含6000万个细胞的LGG粉，每日两次，最短7天，或直至腹泻停止，同时根据世界卫生组织方案用ORS和/或静脉输液纠正脱水，对培养阳性的患者使用抗生素。研究了腹泻和呕吐的持续时间及频率。数据用SPSS - 10软件进行分析。采用学生t检验和卡方检验计算统计学显著性。
该研究包括235例患者，随机分为两组，病例组（117例）和对照组（118例）。两组在年龄、母乳喂养婴儿数量、脱水表现、蛋白质能量营养不良程度及感染分布方面相似。90例（38.3%）患者粪便培养呈阳性，大肠杆菌是最常见的病原体，其次是志贺菌属和艰难梭菌。病例组腹泻的平均持续时间显著低于对照组（5.3天对9.2天）。病例组的平均住院时间也显著更短。未观察到所用LGG剂量引起的并发症。
LGG（6000万个细胞的剂量）可降低PD患者腹泻和呕吐的频率及持续时间，并缩短住院时间。
