硬癌型胃癌预后的回顾性分析：单机构经验

Retrospective analysis of prognosis for scirrhous-type gastric cancer: one institution's experience.

作者信息

Nakamura Rieko, Saikawa Yoshiro, Wada Norihito, Yoshida Masashi, Kubota Tetsuro, Kumai Koichiro, Kitajima Masaki

机构信息

Department of Surgery, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan.

出版信息

Int J Clin Oncol. 2007 Aug;12(4):291-4. doi: 10.1007/s10147-007-0683-9. Epub 2007 Aug 20.

DOI:10.1007/s10147-007-0683-9

PMID:17701009

Abstract

BACKGROUND

Scirrhous gastric cancer is biologically aggressive, and the prognosis is poor even with curative surgery. We compared outcomes with different therapies in order to identify prognostic factors.

METHODS

Records for 83 patients, who were treated between 1991 and 2004, were evaluated for survival and stage, treatment, and clinicopathological factors.

RESULTS

Cumulative 5-year overall survival was 10.2% for all 83 patients, including 27 (32.5%) patients with stage II/III disease and 56 (67.4%) with stage IV disease. The 5-year overall survival rate and median survival time for patients with stage II/III disease after curative surgery were 24.3% and 1150 days. For patients with stage IV disease, 2-year and 5-year survival rates after initial surgery were 13.7% and 0% and median survival was 250 days. In contrast, preoperative chemotherapy for advanced, unresectable disease produced 2-year and 3-year overall survival rates of 53.6% and 26.8% and medican survival was 910 days.

CONCLUSION

Aggressive surgery alone does not seem to improve outcome, but preoperative chemotherapy might be beneficial and should be investigated further.

摘要

背景

硬癌性胃癌具有生物学侵袭性，即使进行根治性手术，预后也很差。我们比较了不同治疗方法的结果，以确定预后因素。

方法

对1991年至2004年间接受治疗的83例患者的记录进行评估，分析其生存情况、分期、治疗方法及临床病理因素。

结果

83例患者的累积5年总生存率为10.2%，其中Ⅱ/Ⅲ期疾病患者27例（32.5%），Ⅳ期疾病患者56例（67.4%）。根治性手术后Ⅱ/Ⅲ期疾病患者的5年总生存率和中位生存时间分别为24.3%和1150天。对于Ⅳ期疾病患者，初次手术后的2年和5年生存率分别为13.7%和0%，中位生存时间为250天。相比之下，针对晚期不可切除疾病的术前化疗产生的2年和3年总生存率分别为53.6%和26.8%，中位生存时间为910天。