Steinberg J, Schwertner C, de Villiers E M, Mir-Salim P, Kiesslich R, Stoelzel U, Scherübl H
Klinik für Innere Medizin, Gastroenterologie und Gastrointestinale Onkologie, Vivantes Klinikum Am Urban, Berlin.
Z Gastroenterol. 2007 Aug;45(8):710-4. doi: 10.1055/s-2007-963205.
Patients suffering from head and neck cancer (HNC) have or will develop a second esophageal squamous cell cancer (ESCC) in 5 - 14 %. When a second esophageal neoplasm occurs in a HNC patient, the prognosis is generally determined by the ESCC, and unfortunately it is poor. Prospective clinical studies in Japan, Brazil, Taiwan, France and Germany have shown that screening or surveillance using Lugol chromoesophagoscopy enables early detection of second esophageal neoplasias. Such a surveillance results in a survival benefit for HNC patients. Vice versa, ESCC patients also have a risk of 9.3 - 11.4 % for a head and neck cancer. Periodic otolaryngeal examination and pharyngoscopy is recommended for curatively treated ESCC patients. Patients with a so-called field cancerisation of the airways and upper digestive tract thus require an interdisciplinary management and monitoring.
患有头颈癌（HNC）的患者中有5% - 14%已经或将会罹患第二原发性食管鳞状细胞癌（ESCC）。当HNC患者出现第二原发性食管肿瘤时，其预后通常由ESCC决定，而不幸的是预后较差。日本、巴西、台湾、法国和德国的前瞻性临床研究表明，使用卢戈氏染色食管镜进行筛查或监测能够早期发现第二原发性食管肿瘤。这种监测可为HNC患者带来生存获益。反之，ESCC患者也有9.3% - 11.4%的风险患头颈癌。对于接受了根治性治疗的ESCC患者，建议定期进行耳鼻喉检查和喉镜检查。因此，患有气道和上消化道所谓场癌化的患者需要进行多学科管理和监测。
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