Hlebowicz Maria, Smiatacz Tomasz, Kowalik Maciej Michal, Trocha Hanna
Klinika Chorób Zakaźnych Akademii Medycznej w Gdansku.
Przegl Epidemiol. 2007;61(1):35-42.
To assess the relationship between inflammatory changes in cerebrospinal fluid (CSF) and prognosis in patients with acute viral encephalitis (AVE).
retrospective medical records analysis of 99 cases of AVE, 37 females and 62 males, age 4-71. Patients were assigned to 2 subgroups: group I--without inflammatory changes in CSF (cytosis < or = 10/mm3 - 40 cases) and group II--with detectable abnormalities in CSF (cytosis >10/mm3 - 59 cases). Long term prognosis and unfavorable outcome were assessed at the moment of discharge from hospital and with a use of questionnaire sent to patients and were described as: 0--complete recovery, 1--long-term disabilities, 2--death.
Among 99 patients with acute viral encephalitis complete recovery was observed in 61% of cases, in 32% the disease resulted in long term consequences and disabilities and 7% died from reasons related to encephalitis.
Patients without inflammatory changes in CSF statistically significantly (p < 0.05) more frequently suffered from coma, early epileptic episodes, respiratory disorders, unfavorable outcome and epilepsy. In a group II statistically significantly more often fever and Herpes simplex etiology were observed.
(1) Among 99 patients in 32% AVE resulted in long-term (subtle as well as severe) disabilities and 7% died from reasons related to AVE. (2) Patients without inflammatory abnormalities in CSF tended to have more severe clinical course and worse prognosis than those with detectable increase of CSF cytosis (>10 cells/mm3).
评估急性病毒性脑炎（AVE）患者脑脊液（CSF）炎症变化与预后之间的关系。
对99例AVE患者进行回顾性病历分析，其中女性37例，男性62例，年龄4至71岁。患者被分为2个亚组：第一组——脑脊液无炎症变化（细胞数≤10/mm³，共40例）；第二组——脑脊液有可检测到的异常（细胞数>10/mm³，共59例）。在出院时以及通过向患者发送问卷来评估长期预后和不良结局，描述如下：0——完全康复；1——长期残疾；2——死亡。
在99例急性病毒性脑炎患者中，61%的病例观察到完全康复，32%的病例疾病导致长期后果和残疾，7%的患者死于与脑炎相关的原因。
脑脊液无炎症变化的患者在统计学上更频繁地出现昏迷、早期癫痫发作、呼吸障碍、不良结局和癫痫（p<0.05）。在第二组中，统计学上更常观察到发热和单纯疱疹病因。
（1）在99例患者中，32%的AVE导致长期（轻微以及严重）残疾，7%的患者死于与AVE相关的原因。（2）脑脊液无炎症异常的患者往往比脑脊液细胞数有可检测到增加（>10个细胞/mm³）的患者临床病程更严重，预后更差。
