Bunker C H, Wing R R, Mallinger A G, Becker D J, Matthews K A, Kuller L H
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
J Hum Hypertens. 1991 Oct;5(5):381-92.
The objectives of this study were to assess the possible role of insulin as a regulator of red blood cell sodium-lithium countertransport and to examine the relationship of countertransport activity to change over time in insulin, blood pressure, and other variables. At baseline, countertransport was measured, and at baseline and after 2-3 years of follow-up, blood pressure, body mass index (BMI), lipids, fasting and two-hour plasma insulin and glucose were measured in 144 white healthy, premenopausal women, age 42-50 years. At baseline, using high and low categories of fasting insulin, triglycerides and BMI, countertransport was independently related to fasting insulin (P = 0.017), and triglycerides (P = 0.001), but not to BMI by analysis of variance. In similar analyses with fasting insulin, BMI, and countertransport, diastolic blood pressure was independently related only to countertransport (P = 0.003). Among the 73 who remained premenopausal after 2-3 year follow-up, baseline countertransport was significantly correlated with increases in fasting and two-hour insulin (r = 0.37, 0.38, P = 0.003, respectively), and these relationships remained significant after adjustment for change in BMI. Among subjects with high baseline countertransport, systolic blood pressure increased 5.6 mmHg compared with -2.2 mmHg with low countertransport, P = 0.001 after adjusting for baseline and change in BMI, triglycerides, and fasting and two-hour insulin. The data are consistent with a role for insulin and lipids in the regulation of sodium transport which may, in turn, play a role in blood pressure regulation. A relatively short follow-up in this healthy population suggests a relationship of baseline countertransport to changes in insulin metabolism, and blood pressure.
本研究的目的是评估胰岛素作为红细胞钠-锂逆向转运调节因子的潜在作用，并研究逆向转运活性与胰岛素、血压及其他变量随时间变化的关系。在基线时测量逆向转运，在基线以及随访2至3年后，对144名年龄在42至50岁的健康绝经前白人女性测量血压、体重指数（BMI）、血脂、空腹及两小时血浆胰岛素和血糖。在基线时，根据空腹胰岛素、甘油三酯和BMI的高低分类，通过方差分析发现逆向转运与空腹胰岛素（P = 0.017）和甘油三酯（P = 0.001）独立相关，但与BMI无关。在对空腹胰岛素、BMI和逆向转运进行的类似分析中，舒张压仅与逆向转运独立相关（P = 0.003）。在2至3年随访后仍处于绝经前的73名女性中，基线逆向转运与空腹及两小时胰岛素的增加显著相关（r分别为0.37、0.38，P均 = 0.003），在对BMI变化进行校正后，这些关系仍然显著。在基线逆向转运高的受试者中，收缩压升高了5.6 mmHg，而逆向转运低的受试者收缩压降低了2.2 mmHg，在校正基线、BMI、甘油三酯以及空腹和两小时胰岛素的变化后，P = 0.001。这些数据表明胰岛素和脂质在钠转运调节中起作用，而钠转运调节可能反过来在血压调节中起作用。对这一健康人群相对较短的随访表明基线逆向转运与胰岛素代谢和血压变化之间存在关联。
