Hattingh J, Pitts N I, de Vos V, Moyes D G, Ganhao M F
Department of General Physiology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
J S Afr Vet Assoc. 1991 Sep;62(3):126-9.
The time which elapses before cessation of breathing, and blood pressure and blood gas changes after the intramuscular administration of suxamethonium, or a mixture of suxamethonium and hexamethonium, is compared in immobilised African elephants (Loxodonta africana) and buffaloes (Syncerus caffer). In addition, the respiratory responses of elephants and other animals to intravenous administration of suxamethonium and succinylmonocholine are reported on, as are the effects of darting animals with succinylmonocholine. The results show that respiration is affected in a similar fashion in all species investigated. However, the characteristic gradual decrease in respiratory rate seen in elephants during culling, using suxamethonium, resembles the effects observed when succinylmonocholine is administered. It is suggested that elephants are killed by this first breakdown product of suxamethonium during culling and/or that unique acetylcholine receptors may be involved.
比较了在固定的非洲象（Loxodonta africana）和水牛（Syncerus caffer）中，肌肉注射琥珀酰胆碱或琥珀酰胆碱与六甲铵的混合物后，呼吸停止前经过的时间以及血压和血气变化。此外，还报告了大象和其他动物对静脉注射琥珀酰胆碱和琥珀酰单胆碱的呼吸反应，以及用琥珀酰单胆碱麻醉动物的效果。结果表明，在所研究的所有物种中，呼吸受到的影响方式相似。然而，在扑杀大象时使用琥珀酰胆碱所观察到的呼吸频率逐渐下降的特征，类似于注射琥珀酰单胆碱时观察到的效果。有人认为，在扑杀过程中，大象是被琥珀酰胆碱的这种首个分解产物致死的，和/或可能涉及独特的乙酰胆碱受体。
