Ohmura A, Wong K C, Shaw L
Can Anaesth Soc J. 1976 Nov;23(6):567-73. doi: 10.1007/BF03006737.
The present study evaluated possible contribution of succinylmonocholine in producing serious cardiovascular effects with or without succinyldicholine, using albino rabbits as the experimental animal. Forty-eight experiments were performed, 22 in vivo and 26 in vitro (Langendort heart). Succinyldicholine and succinylmonocholine administered separately or together produced an immediate bradycardia in vivo as well as in vitro. The combination of these drugs had a direct arhythmogenic effect as well as an indirect reflux mediated cardiac effect. When succinyldicholine was given within five minutes following a dose of succinylmonocholine there was significant nodal and ventricular ectopic beats, but no bradycardia. Dysrhythmias in in vivo hearts were abolished by cord trans-section, trimethaphan and reserpine pretreatment. There was no evidence in vivo that succinylmonocholine produced more serious bradycardia, dysrhythmias or hypotension than succinyldicholine,
本研究以白化兔为实验动物，评估了琥珀酰单胆碱在有或没有琥珀酰二胆碱的情况下产生严重心血管效应的可能作用。共进行了48项实验，其中22项在体内进行，26项在体外（Langendort心脏）进行。单独或联合给予琥珀酰二胆碱和琥珀酰单胆碱在体内和体外均能立即引起心动过缓。这些药物的组合具有直接的致心律失常作用以及间接的反流介导的心脏效应。在给予琥珀酰单胆碱剂量后五分钟内给予琥珀酰二胆碱时，出现明显的结性和室性异位搏动，但无心动过缓。体内心脏的心律失常可通过切断脊髓、三甲噻方和利血平预处理消除。在体内没有证据表明琥珀酰单胆碱比琥珀酰二胆碱产生更严重的心动过缓、心律失常或低血压。
