Key Laboratory of Animal Models and Human Disease Mechanisms, Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, and Graduate School of Chinese Academy of Sciences, Beijing 100039, China.
Neurosci Bull. 2006 May;22(3):137-43.
To investigate whether repeated morphine exposure or prolonged withdrawal could influence operant and spatial learning differentially.
Animals were chronically treated with morphine or subjected to morphine withdrawal. Then, they were subjected to two kinds of learning: operant conditioning and spatial learning.
The acquisition of both simple appetitive and cued operant learning was impaired after repeated morphine treatment. Withdrawal for 5 weeks alleviated the impairments. Single morphine exposure disrupted the retrieval of operant memory but had no effect on rats after 5-week withdrawal. Contrarily, neither chronic morphine exposure nor 5-week withdrawal influenced spatial learning task of the Morris water maze. Nevertheless, the retrieval of spatial memory was impaired by repeated morphine exposure but not by 5-week withdrawal.
These observations suggest that repeated morphine exposure can influence different types of learning at different aspects, implicating that the formation of opiate addiction may usurp memory mechanisms differentially.
探讨重复吗啡暴露或延长戒断是否会对操作性和空间学习产生不同影响。
动物进行慢性吗啡处理或经历吗啡戒断。然后，它们接受两种学习：操作性条件反射学习和空间学习。
重复吗啡处理后，简单的食欲性和提示性操作性学习的获得都受到损害。5 周戒断缓解了这些损伤。单次吗啡暴露会破坏操作性记忆的检索，但对 5 周戒断后的大鼠没有影响。相反，慢性吗啡暴露或 5 周戒断均不影响 Morris 水迷宫的空间学习任务。然而，重复吗啡暴露会损害空间记忆的检索，但 5 周戒断不会。
这些观察结果表明，重复吗啡暴露可以在不同方面影响不同类型的学习，这表明阿片类药物成瘾的形成可能会以不同的方式侵占记忆机制。
