Taylor J H, Guthrie A J, Leisewitz A
Department of Physiology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
J S Afr Vet Assoc. 1991 Dec;62(4):153-5.
Carboxyhaemoglobin fractions were found to be significantly higher (P less than 0.05) in dogs (n = 5) with severe babesiosis than in control subjects (n = 5). The enzymatic conversion of haem to biliverdin by haem oxygenase is the only known source of endogenous carbon monoxide. We propose that the increased production of endogenous carbon monoxide following the haemolysis associated with babesiosis, results in the carboxyhaemoglobinaemia observed in this study. The superimposition of carboxyhaemoglobinaemia on severe anaemia results in further compromise of the oxygen status of dogs with severe babesiosis, and probably plays a role in the pathogenesis of the hypoxic tissue damage associated with this condition.
研究发现，患有严重巴贝斯虫病的犬类（n = 5）的碳氧血红蛋白分数显著高于对照组（n = 5）（P < 0.05）。血红素加氧酶将血红素酶促转化为胆绿素是内源性一氧化碳的唯一已知来源。我们认为，与巴贝斯虫病相关的溶血后内源性一氧化碳产生增加，导致了本研究中观察到的碳氧血红蛋白血症。碳氧血红蛋白血症叠加在严重贫血上，会进一步损害患有严重巴贝斯虫病犬类的氧状态，并且可能在与此病症相关的缺氧性组织损伤的发病机制中起作用。
