Lobetti R G, Reyers F
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J S Afr Vet Assoc. 1996 Jun;67(2):88-90.
Higher levels of urinary met-haemoglobin were found in dogs with naturally occurring Babesia canis infection (n = 6) than in control subjects (n = 5). The urinary haemoglobin in the affected cases ranged from 1 to 4 g/l of which 28-95% was met-haemoglobin. This was a significant finding in that met-haemoglobin has been shown to be nephrotoxic in the dog, especially in the presence of aciduria. Acidic urine was also demonstrated in those dogs with B. canis infection, which may aggravate the nephrotoxic effect of the met-haemoglobinuria. Thus naturally infected B. canis cases showing haemoglobinuria may in fact have significant met-haemoglobinaemia, which may predispose them to renal disease.
在自然感染犬巴贝斯虫的犬只（n = 6）中，发现其尿中高铁血红蛋白水平高于对照组（n = 5）。患病犬只的尿血红蛋白含量为1至4 g/l，其中高铁血红蛋白占28 - 95%。这一发现具有重要意义，因为高铁血红蛋白已被证明对犬具有肾毒性，尤其是在存在酸性尿的情况下。感染犬巴贝斯虫的犬只也出现了酸性尿，这可能会加重高铁血红蛋白尿的肾毒性作用。因此，自然感染犬巴贝斯虫且出现血红蛋白尿的病例实际上可能存在显著的高铁血红蛋白血症，这可能使它们易患肾脏疾病。
